Progressive pseudorheumatoid arthropathy of childhood (PPAC; MIM 208230) is an autosomal recessively inherited arthropathy due to mutations in the WISP3 gene. The WISP3 gene codes for WNT1-inducible signaling pathway protein 3. PPAC is a progressive disorder with childhood onset. Fatigue, muscle weakness, waddling gait, bowed legs and joint stiffness may be early manifestations.read more

Tests Available

By gene: WISP3
Sanger Sequencing
$830
Test Code: 1276
Deletion / Duplication
$680
Test Code: 1277
Sanger/Del Dup Comprehensive
$1,410
Test Code: 1631

Test Details

Technical Information
Genes: 
WISP3
Disease Groups: 
Skeletal Dysplasias
MIM: 
208230
Billing
Price: 
$830
CPT Codes: 
81479 x 1
Ordering
SKU:
1276
Turnaround Time: 
Typically 1 to 2 weeks from receipt of a sample in the laboratory. All cases involving ongoing pregnancies will be expedited.
Non-Prenatal Specimens: 
  1. Whole blood: purple-top (EDTA) tube, minimum of 3 ml
  2. Genomic DNA: minimum of 10 µg (at a concentration of at least 50 ng/µl)
  3. Fibroblasts: 4 confluent T-25 flasks
  4. Saliva: only samples collected in Oragene DNA Self-Collection Kit or Oragene Saliva Collection Kit for Young Children are accepted
Prenatal Specimens: 
  1. Cultured cells: 4 confluent T-25 flasks derived from amnio or CVS samples
  2. Genomic DNA: minimum of 10 µg (at a concentration of at least 50 ng/µl)
Shipping: 

Ship all specimen types at room temperature by overnight courier. Do not freeze.

Search Tests

TIP: enter a partial disorder name or gene to widen your search