Van der Woude syndrome (VWS) is the most common syndromic form of cleft lip and palate. It is an autosomal dominant disorder characterized by pits and/or sinuses of the lower lip, cleft lip, cleft palate and uvular anomalies. Other findings may include ankyloglossia and hypodontia. VWS1 (MIM 119300) and VWS2 (MIM 606713) are caused by mutations in the IRF6 and GRHL3 genes, respectively.read more
Tests Available
By gene: IRF6
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Sanger Sequencing
$680
Test Code: 2307
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Deletion / Duplication
$680
Test Code: 2308
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Sanger/Del Dup Comprehensive
$1,260
Test Code: 2309
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Related Panels
Test Details
Technical Information
Genes:
IRF6
Disease Groups:
Craniosynostosis and Craniofacial Disorders
MIM:
119300
Billing
Price:
$680
CPT Codes:
81479 x 1
Ordering
SKU:
2307 Turnaround Time:
Typically 1 to 2 weeks from receipt of a sample in the laboratory. All cases involving ongoing pregnancies will be expedited.
Non-Prenatal Specimens:
- Whole blood: purple-top (EDTA) tube, minimum of 3 ml
- Genomic DNA: minimum of 10 µg (at a concentration of at least 50 ng/µl)
- Fibroblasts: 4 confluent T-25 flasks
- Saliva: only samples collected in Oragene DNA Self-Collection Kit or Oragene Saliva Collection Kit for Young Children are accepted
Prenatal Specimens:
- Cultured cells: 4 confluent T-25 flasks derived from amnio or CVS samples
- Genomic DNA: minimum of 10 µg (at a concentration of at least 50 ng/µl)
Shipping:
Ship all specimen types at room temperature by overnight courier. Do not freeze.